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Yingxian Xiao Selected Research

sazetidine-A

5/2014Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain.
10/2013Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.
4/2013Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.
5/2012Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.
6/2011Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.
8/2010Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.
9/2008Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.

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Yingxian Xiao Research Topics

Disease

4Tobacco Use Disorder (Nicotine Dependence)
05/2014 - 08/2010
2Hypothermia
10/2013 - 05/2012
1Acquired Immunodeficiency Syndrome (AIDS)
09/2017
1Body Weight (Weight, Body)
09/2017
1Mood Disorders (Mood Disorder)
02/2016
1Blepharoptosis (Ptosis, Eyelid)
02/2016
1Depressive Disorder (Melancholia)
02/2016
1Alzheimer Disease (Alzheimer's Disease)
05/2015
1Schizophrenia (Dementia Praecox)
05/2015
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
05/2014
1Weight Gain
05/2014
1Central Nervous System Diseases (CNS Diseases)
04/2014
1Alcoholism (Alcohol Abuse)
04/2013
1Mental Disorders (Mental Disorder)
06/2011
1Cognitive Dysfunction
06/2011
1Seizures (Absence Seizure)
09/2008
1Pain (Aches)
09/2008
1Insulinoma
03/2006

Drug/Important Bio-Agent (IBA)

7sazetidine-AIBA
05/2014 - 09/2008
6Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
09/2017 - 03/2006
6NicotineFDA Link
05/2014 - 03/2006
23- (azetidin- 2- ylmethoxy)- 5- (phenylethynyl)pyridineIBA
09/2017 - 10/2013
2Cholinergic ReceptorsIBA
04/2014 - 04/2013
1YL-2-203IBA
09/2017
1Methadone (Dolophine)FDA LinkGeneric
02/2016
1MecamylamineIBA
02/2016
1Pharmaceutical PreparationsIBA
02/2016
1Anti-Anxiety Agents (Anxiolytics)IBA
05/2014
1pyridineIBA
04/2013
1Analgesics (Analgesic Drugs)IBA
09/2008
1Formaldehyde (Formol)FDA Link
09/2008
1epibatidineIBA
09/2008
1CalciumIBA
03/2006
1Insulin (Novolin)FDA Link
03/2006
1RubidiumIBA
03/2006

Therapy/Procedure

2Therapeutics
04/2013 - 11/2012
1Drug Therapy (Chemotherapy)
02/2016
1Induced Hypothermia
10/2013
1Analgesia
09/2008